Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.
Identifieur interne : 003005 ( Main/Exploration ); précédent : 003004; suivant : 003006Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.
Auteurs : Dale R. Nyholt [Australie] ; Verneri Anttila [États-Unis] ; Bendik S. Winsvold [Norvège] ; Tobias Kurth [États-Unis] ; Hreinn Stefansson [Islande] ; Mikko Kallela [Finlande] ; Rainer Malik [Allemagne] ; Boukje De Vries [Pays-Bas] ; Gisela M. Terwindt [Pays-Bas] ; M Arfan Ikram [Pays-Bas] ; Anine H. Stam [Pays-Bas] ; Lannie Ligthart [Pays-Bas] ; Tobias Freilinger [Allemagne] ; Michael Alexander [Allemagne] ; Bertram Muller-Myhsok [Allemagne] ; Stefan Schreiber [Allemagne] ; Thomas Meitinger [Allemagne] ; Arpo Aromaa [Finlande] ; Johan G. Eriksson [Finlande] ; Jaakko Kaprio [Finlande] ; Dorret I. Boomsma [Pays-Bas] ; Cornelia Van Duijn [Pays-Bas] ; Olli Raitakari [Finlande] ; Marjo-Riitta J Rvelin [Finlande] ; John-Anker Zwart [Norvège] ; Lydia Quaye [Royaume-Uni] ; David P. Strachan [Royaume-Uni] ; Christian Kubisch [Allemagne] ; Michel D. Ferrari [Pays-Bas] ; Arn M J M. Van Den Maagdenberg [Pays-Bas] ; Martin Dichgans [Allemagne] ; Maija Wessman [Finlande] ; George Davey Smith [Royaume-Uni] ; Kari Stefansson [Islande] ; Daniel I. Chasman [États-Unis] ; Aarno Palotie [États-Unis]Source :
- Cephalalgia : an international journal of headache [ 1468-2982 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- classification : Migraine Disorders.
- genetics : Migraine Disorders.
- Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide.
Abstract
There has been intensive debate whether migraine with aura (MA) and migraine without aura (MO) should be considered distinct subtypes or part of the same disease spectrum. There is also discussion to what extent migraine cases collected in specialised headache clinics differ from cases from population cohorts, and how female cases differ from male cases with respect to their migraine. To assess the genetic overlap between these migraine subgroups, we examined genome-wide association (GWA) results from analysis of 23,285 migraine cases and 95,425 population-matched controls.
DOI: 10.1177/0333102414547784
PubMed: 25179292
Affiliations:
- Allemagne, Australie, Finlande, Islande, Norvège, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, District de Haute-Bavière, District de Tübingen, Finlande occidentale, Grand Londres, Uusimaa
- Helsinki, Londres, Munich, Turku, Ulm
- Université Louis-et-Maximilien de Munich, Université d'Helsinki, Université d'Ulm, Université de Londres, Université de Turku, Université technique de Munich
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Nyholt</name><affiliation wicri:level="1"><nlm:affiliation>Neurogenetics Laboratory, QIMR Berghofer, Australia Dale.Nyholt@qimrberghofer.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Neurogenetics Laboratory, QIMR Berghofer</wicri:regionArea><wicri:noRegion>QIMR Berghofer</wicri:noRegion></affiliation></author><author><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name><affiliation wicri:level="1"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Harvard Medical School, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Harvard Medical School, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT</wicri:regionArea><wicri:noRegion>Broad Institute of Harvard and MIT</wicri:noRegion></affiliation></author><author><name sortKey="Winsvold, Bendik S" sort="Winsvold, Bendik S" uniqKey="Winsvold B" first="Bendik S" last="Winsvold">Bendik S. Winsvold</name><affiliation wicri:level="1"><nlm:affiliation>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo</wicri:regionArea><wicri:noRegion>Oslo University Hospital and University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM) Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, France University of Bordeaux, France Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, France University of Bordeaux, France Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School</wicri:regionArea><wicri:noRegion>Harvard Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics</wicri:regionArea></affiliation></author><author><name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Helsinki University Central Hospital</wicri:regionArea><wicri:noRegion>Helsinki University Central Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität</wicri:regionArea><wicri:noRegion>Ludwig-Maximilians-Universität</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Vries, Boukje De" sort="Vries, Boukje De" uniqKey="Vries B" first="Boukje De" last="Vries">Boukje De Vries</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M" last="Terwindt">Gisela M. Terwindt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands Department of Radiology, Erasmus University Medical Centre, the Netherlands Department of Neurology, Erasmus University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands Department of Radiology, Erasmus University Medical Centre, the Netherlands Department of Neurology, Erasmus University Medical Centre</wicri:regionArea><wicri:noRegion>Erasmus University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Stam, Anine H" sort="Stam, Anine H" uniqKey="Stam A" first="Anine H" last="Stam">Anine H. Stam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Ligthart, Lannie" sort="Ligthart, Lannie" uniqKey="Ligthart L" first="Lannie" last="Ligthart">Lannie Ligthart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, the Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, the Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre</wicri:regionArea><wicri:noRegion>VU University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Department of Neurology, Klinikum der Universität München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Department of Neurology, Klinikum der Universität München</wicri:regionArea><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Alexander, Michael" sort="Alexander, Michael" uniqKey="Alexander M" first="Michael" last="Alexander">Michael Alexander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genomics, Life & Brain Center, University of Bonn, Germany Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Germany Institute of Human Genetics, University of Bonn</wicri:regionArea><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Muller-Myhsok">Bertram Muller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:regionArea><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Molecular Biology, Christian Albrechts University, Germany Department of Internal Medicine I, Christian Albrechts University, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian Albrechts University, Germany Department of Internal Medicine I, Christian Albrechts University</wicri:regionArea><wicri:noRegion>Christian Albrechts University</wicri:noRegion><wicri:noRegion>Christian Albrechts University</wicri:noRegion><wicri:noRegion>Christian Albrechts University</wicri:noRegion></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Human Genetics, Helmholtz Center Munich, Germany Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz Center Munich, Germany Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München</wicri:regionArea><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Aromaa, Arpo" sort="Aromaa, Arpo" uniqKey="Aromaa A" first="Arpo" last="Aromaa">Arpo Aromaa</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="4"><nlm:affiliation>National Institute for Health and Welfare, Finland Institute of Genetics, Folkhälsan Research Center, Finland Department of General Practice, Helsinki University Central Hospital, Helsinki, Finland Vaasa Central Hospital, Finland Department of General Practice and Primary Health Care, University of Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Finland Institute of Genetics, Folkhälsan Research Center, Finland Department of General Practice, Helsinki University Central Hospital, Helsinki, Finland Vaasa Central Hospital, Finland Department of General Practice and Primary Health Care, University of Helsinki</wicri:regionArea><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Department of Public Health, Hjelt Institute, University of Helsinki, Finland Department of Mental Health and Alcohol Research, National Institute for Health and Welfare, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Department of Public Health, Hjelt Institute, University of Helsinki, Finland Department of Mental Health and Alcohol Research, National Institute for Health and Welfare</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University</wicri:regionArea><wicri:noRegion>VU University</wicri:noRegion></affiliation></author><author><name sortKey="Duijn, Cornelia Van" sort="Duijn, Cornelia Van" uniqKey="Duijn C" first="Cornelia Van" last="Duijn">Cornelia Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Centre</wicri:regionArea><wicri:noRegion>Erasmus University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Health Sciences, University of Oulu, Finland Unit of Primary Care, Oulu University Hospital, Finland Department of Children, Young People and Families, National Institute for Health and Welfare, Finland Department of Epidemiology and Biostatistics, School of Public Health, MRC-Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College, UK Biocenter Oulu, University of Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Finland Unit of Primary Care, Oulu University Hospital, Finland Department of Children, Young People and Families, National Institute for Health and Welfare, Finland Department of Epidemiology and Biostatistics, School of Public Health, MRC-Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College, UK Biocenter Oulu, University of Oulu</wicri:regionArea><wicri:noRegion>University of Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Zwart, John Anker" sort="Zwart, John Anker" uniqKey="Zwart J" first="John-Anker" last="Zwart">John-Anker Zwart</name><affiliation wicri:level="1"><nlm:affiliation>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo</wicri:regionArea><wicri:noRegion>Oslo University Hospital and University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Quaye, Lydia" sort="Quaye, Lydia" uniqKey="Quaye L" first="Lydia" last="Quaye">Lydia Quaye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation wicri:level="4"><nlm:affiliation>Division of Population Health Sciences and Education, St George's, University of London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Population Health Sciences and Education, St George's, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany Institute of Human Genetics, University of Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany Institute of Human Genetics, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D" last="Ferrari">Michel D. Ferrari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M J M" last="Van Den Maagdenberg">Arn M J M. Van Den Maagdenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Leiden University Medical Centre, the Netherlands Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre, the Netherlands Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:regionArea><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Wessman, Maija" sort="Wessman, Maija" uniqKey="Wessman M" first="Maija" last="Wessman">Maija Wessman</name><affiliation wicri:level="1"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Institute of Genetics, Folkhälsan Research Center, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Institute of Genetics, Folkhälsan Research Center</wicri:regionArea><wicri:noRegion>Folkhälsan Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine</wicri:regionArea><wicri:noRegion>School of Social and Community Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Iceland School of Medicine, University of Iceland, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Iceland School of Medicine, University of Iceland</wicri:regionArea><wicri:noRegion>University of Iceland</wicri:noRegion></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School</wicri:regionArea><wicri:noRegion>Harvard Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="4"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, USA Department of Neurology, Massachusetts General Hospital, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, USA Department of Neurology, Massachusetts General Hospital</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25179292</idno><idno type="pmid">25179292</idno><idno type="doi">10.1177/0333102414547784</idno><idno type="wicri:Area/PubMed/Corpus">002D85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D85</idno><idno type="wicri:Area/PubMed/Curation">002D10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D10</idno><idno type="wicri:Area/PubMed/Checkpoint">002D10</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D10</idno><idno type="wicri:Area/Ncbi/Merge">001D67</idno><idno type="wicri:Area/Ncbi/Curation">001D67</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D67</idno><idno type="wicri:Area/Main/Merge">003006</idno><idno type="wicri:Area/Main/Curation">003005</idno><idno type="wicri:Area/Main/Exploration">003005</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.</title><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><nlm:affiliation>Neurogenetics Laboratory, QIMR Berghofer, Australia Dale.Nyholt@qimrberghofer.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Neurogenetics Laboratory, QIMR Berghofer</wicri:regionArea><wicri:noRegion>QIMR Berghofer</wicri:noRegion></affiliation></author><author><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name><affiliation wicri:level="1"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Harvard Medical School, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Harvard Medical School, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT</wicri:regionArea><wicri:noRegion>Broad Institute of Harvard and MIT</wicri:noRegion></affiliation></author><author><name sortKey="Winsvold, Bendik S" sort="Winsvold, Bendik S" uniqKey="Winsvold B" first="Bendik S" last="Winsvold">Bendik S. Winsvold</name><affiliation wicri:level="1"><nlm:affiliation>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo</wicri:regionArea><wicri:noRegion>Oslo University Hospital and University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM) Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, France University of Bordeaux, France Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, France University of Bordeaux, France Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School</wicri:regionArea><wicri:noRegion>Harvard Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics</wicri:regionArea></affiliation></author><author><name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Helsinki University Central Hospital</wicri:regionArea><wicri:noRegion>Helsinki University Central Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität</wicri:regionArea><wicri:noRegion>Ludwig-Maximilians-Universität</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Vries, Boukje De" sort="Vries, Boukje De" uniqKey="Vries B" first="Boukje De" last="Vries">Boukje De Vries</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M" last="Terwindt">Gisela M. Terwindt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands Department of Radiology, Erasmus University Medical Centre, the Netherlands Department of Neurology, Erasmus University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands Department of Radiology, Erasmus University Medical Centre, the Netherlands Department of Neurology, Erasmus University Medical Centre</wicri:regionArea><wicri:noRegion>Erasmus University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Stam, Anine H" sort="Stam, Anine H" uniqKey="Stam A" first="Anine H" last="Stam">Anine H. Stam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Ligthart, Lannie" sort="Ligthart, Lannie" uniqKey="Ligthart L" first="Lannie" last="Ligthart">Lannie Ligthart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, the Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, the Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre</wicri:regionArea><wicri:noRegion>VU University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Department of Neurology, Klinikum der Universität München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Department of Neurology, Klinikum der Universität München</wicri:regionArea><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Alexander, Michael" sort="Alexander, Michael" uniqKey="Alexander M" first="Michael" last="Alexander">Michael Alexander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genomics, Life & Brain Center, University of Bonn, Germany Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Germany Institute of Human Genetics, University of Bonn</wicri:regionArea><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Muller-Myhsok">Bertram Muller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:regionArea><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Molecular Biology, Christian Albrechts University, Germany Department of Internal Medicine I, Christian Albrechts University, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian Albrechts University, Germany Department of Internal Medicine I, Christian Albrechts University</wicri:regionArea><wicri:noRegion>Christian Albrechts University</wicri:noRegion><wicri:noRegion>Christian Albrechts University</wicri:noRegion><wicri:noRegion>Christian Albrechts University</wicri:noRegion></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Human Genetics, Helmholtz Center Munich, Germany Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Helmholtz Center Munich, Germany Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München</wicri:regionArea><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Aromaa, Arpo" sort="Aromaa, Arpo" uniqKey="Aromaa A" first="Arpo" last="Aromaa">Arpo Aromaa</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="4"><nlm:affiliation>National Institute for Health and Welfare, Finland Institute of Genetics, Folkhälsan Research Center, Finland Department of General Practice, Helsinki University Central Hospital, Helsinki, Finland Vaasa Central Hospital, Finland Department of General Practice and Primary Health Care, University of Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Finland Institute of Genetics, Folkhälsan Research Center, Finland Department of General Practice, Helsinki University Central Hospital, Helsinki, Finland Vaasa Central Hospital, Finland Department of General Practice and Primary Health Care, University of Helsinki</wicri:regionArea><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Department of Public Health, Hjelt Institute, University of Helsinki, Finland Department of Mental Health and Alcohol Research, National Institute for Health and Welfare, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Department of Public Health, Hjelt Institute, University of Helsinki, Finland Department of Mental Health and Alcohol Research, National Institute for Health and Welfare</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Psychology, VU University, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University</wicri:regionArea><wicri:noRegion>VU University</wicri:noRegion></affiliation></author><author><name sortKey="Duijn, Cornelia Van" sort="Duijn, Cornelia Van" uniqKey="Duijn C" first="Cornelia Van" last="Duijn">Cornelia Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Centre</wicri:regionArea><wicri:noRegion>Erasmus University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Health Sciences, University of Oulu, Finland Unit of Primary Care, Oulu University Hospital, Finland Department of Children, Young People and Families, National Institute for Health and Welfare, Finland Department of Epidemiology and Biostatistics, School of Public Health, MRC-Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College, UK Biocenter Oulu, University of Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Finland Unit of Primary Care, Oulu University Hospital, Finland Department of Children, Young People and Families, National Institute for Health and Welfare, Finland Department of Epidemiology and Biostatistics, School of Public Health, MRC-Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College, UK Biocenter Oulu, University of Oulu</wicri:regionArea><wicri:noRegion>University of Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Zwart, John Anker" sort="Zwart, John Anker" uniqKey="Zwart J" first="John-Anker" last="Zwart">John-Anker Zwart</name><affiliation wicri:level="1"><nlm:affiliation>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>FORMI and Department of Neurology, Oslo University Hospital and University of Oslo</wicri:regionArea><wicri:noRegion>Oslo University Hospital and University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Quaye, Lydia" sort="Quaye, Lydia" uniqKey="Quaye L" first="Lydia" last="Quaye">Lydia Quaye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation wicri:level="4"><nlm:affiliation>Division of Population Health Sciences and Education, St George's, University of London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Population Health Sciences and Education, St George's, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany Institute of Human Genetics, University of Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany Institute of Human Genetics, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D" last="Ferrari">Michel D. Ferrari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M J M" last="Van Den Maagdenberg">Arn M J M. Van Den Maagdenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Leiden University Medical Centre, the Netherlands Department of Neurology, Leiden University Medical Centre, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Centre, the Netherlands Department of Neurology, Leiden University Medical Centre</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:regionArea><wicri:noRegion>Germany Munich Cluster for Systems Neurology (SyNergy)</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Wessman, Maija" sort="Wessman, Maija" uniqKey="Wessman M" first="Maija" last="Wessman">Maija Wessman</name><affiliation wicri:level="1"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Institute of Genetics, Folkhälsan Research Center, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Institute of Genetics, Folkhälsan Research Center</wicri:regionArea><wicri:noRegion>Folkhälsan Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine</wicri:regionArea><wicri:noRegion>School of Social and Community Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics, Iceland School of Medicine, University of Iceland, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Iceland School of Medicine, University of Iceland</wicri:regionArea><wicri:noRegion>University of Iceland</wicri:noRegion></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School</wicri:regionArea><wicri:noRegion>Harvard Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="4"><nlm:affiliation>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, USA Department of Neurology, Massachusetts General Hospital, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, USA Department of Neurology, Massachusetts General Hospital</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author></analytic><series><title level="j">Cephalalgia : an international journal of headache</title><idno type="eISSN">1468-2982</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Migraine Disorders (classification)</term><term>Migraine Disorders (genetics)</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Migraines ()</term><term>Migraines (génétique)</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Migraine Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Migraine Disorders</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Migraines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Migraines</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There has been intensive debate whether migraine with aura (MA) and migraine without aura (MO) should be considered distinct subtypes or part of the same disease spectrum. There is also discussion to what extent migraine cases collected in specialised headache clinics differ from cases from population cohorts, and how female cases differ from male cases with respect to their migraine. To assess the genetic overlap between these migraine subgroups, we examined genome-wide association (GWA) results from analysis of 23,285 migraine cases and 95,425 population-matched controls.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Finlande</li><li>Islande</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Haute-Bavière</li><li>District de Tübingen</li><li>Finlande occidentale</li><li>Grand Londres</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Londres</li><li>Munich</li><li>Turku</li><li>Ulm</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Helsinki</li><li>Université d'Ulm</li><li>Université de Londres</li><li>Université de Turku</li><li>Université technique de Munich</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name></noRegion><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name></country><country name="Norvège"><noRegion><name sortKey="Winsvold, Bendik S" sort="Winsvold, Bendik S" uniqKey="Winsvold B" first="Bendik S" last="Winsvold">Bendik S. Winsvold</name></noRegion><name sortKey="Zwart, John Anker" sort="Zwart, John Anker" uniqKey="Zwart J" first="John-Anker" last="Zwart">John-Anker Zwart</name></country><country name="Islande"><noRegion><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name></noRegion><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name></country><country name="Finlande"><noRegion><name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name></noRegion><name sortKey="Aromaa, Arpo" sort="Aromaa, Arpo" uniqKey="Aromaa A" first="Arpo" last="Aromaa">Arpo Aromaa</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><name sortKey="Wessman, Maija" sort="Wessman, Maija" uniqKey="Wessman M" first="Maija" last="Wessman">Maija Wessman</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name></region><name sortKey="Alexander, Michael" sort="Alexander, Michael" uniqKey="Alexander M" first="Michael" last="Alexander">Michael Alexander</name><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name><name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Muller-Myhsok">Bertram Muller-Myhsok</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name></country><country name="Pays-Bas"><noRegion><name sortKey="Vries, Boukje De" sort="Vries, Boukje De" uniqKey="Vries B" first="Boukje De" last="Vries">Boukje De Vries</name></noRegion><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><name sortKey="Duijn, Cornelia Van" sort="Duijn, Cornelia Van" uniqKey="Duijn C" first="Cornelia Van" last="Duijn">Cornelia Van Duijn</name><name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D" last="Ferrari">Michel D. Ferrari</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><name sortKey="Ligthart, Lannie" sort="Ligthart, Lannie" uniqKey="Ligthart L" first="Lannie" last="Ligthart">Lannie Ligthart</name><name sortKey="Stam, Anine H" sort="Stam, Anine H" uniqKey="Stam A" first="Anine H" last="Stam">Anine H. Stam</name><name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M" last="Terwindt">Gisela M. Terwindt</name><name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M J M" last="Van Den Maagdenberg">Arn M J M. Van Den Maagdenberg</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Quaye, Lydia" sort="Quaye, Lydia" uniqKey="Quaye L" first="Lydia" last="Quaye">Lydia Quaye</name></noRegion><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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